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Article

Asymmetry-defective oligodendrocyte progenitors are glioma precursors.

Cancer cell - 13 Sept 2011

Sugiarto Sista, Persson Anders I, Munoz Elena Gonzalez, Waldhuber Markus, Lamagna Chrystelle, Andor Noemi, Hanecker Patrizia, Ayers-Ringler Jennifer, Phillips Joanna, Siu Jason, Lim Daniel A, Vandenberg Scott, Stallcup William, Berger Mitchel S, Bergers Gabriele, Weiss William A, Petritsch Claudia

Abstract excerpt

Postnatal oligodendrocyte progenitor cells (OPC) self-renew, generate mature oligodendrocytes, and are a cellular origin of oligodendrogliomas. We show that the proteoglycan NG2 segregates asymmetrically during mitosis to generate OPC cells of distinct fate. NG2 is required for asymmetric segrega...

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Source

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Identifiers

PMID: 21907924
DOI: 10.1016/j.ccr.2011.08.011
PMCID: PMC3297490

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21907924-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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