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Article

Genetic Encoding of para-Pentafluorosulfanyl Phenylalanine: A Highly Hydrophobic and Strongly Electronegative Group for Stable Protein Interactions.

Journal of the American Chemical Society - 14 Oct 2020

Qianzhu Haocheng, Welegedara Adarshi P, Williamson Holly, McGrath Amy E, Mahawaththa Mithun C, Dixon Nicholas E, Otting Gottfried, Huber Thomas

Abstract excerpt

SF5Phe, para-pentafluorosulfanyl phenylalanine, is an unnatural amino acid with extreme physicochemical properties, which is stable in physiological conditions. Here we present newly developed aminoacyl-tRNA synthetases that enable genetic encoding of SF5Phe for site-specific incorporation into proteins in high yields. Owing to the SF5 moiety's dichotomy of strong polarity and high hydrophobicity, the unnatural...

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PMID: 32975937
DOI: 10.1021/jacs.0c07976

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