Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics.

Cell - 9 Jul 2020

Li Qingke, Chen Qu, Klauser Paul C, Li Mengyuan, Zheng Feng, Wang Nanxi, Li Xiaoying, Zhang Qianbing, Fu Xuemei, Wang Qian, Xu Yang, Wang Lei

Abstract excerpt

Small molecule covalent drugs provide desirable therapeutic properties over noncovalent ones for treating challenging diseases. The potential of covalent protein drugs, however, remains unexplored due to protein's inability to bind targets covalently. We report a proximity-enabled reactive therapeutics (PERx) approach to generate covalent protein drugs. Through genetic code expansion, a latent bioreactive amino...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ligands
Share to B7-H1 Antigen
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Monocytes

Share to Pharmaceutical Preparations

Share to Receptors, Chimeric Antigen

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 32579975
DOI: 10.1016/j.cell.2020.05.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developing Covalent Protein Drugs via Proximity-Enabled Reactive Therapeutics.PMID 32579975Read ↗

Affinity‐Directed Site‐Specific Protein Labeling and Its Application to Antibody‐Drug ConjugatesSemantic proximity Read ↗

Adding an unnatural covalent bond to proteins through proximity-enhanced bioreactivity.Semantic proximity Read ↗

Precision medicine by designer interference peptides: applications in oncology and molecular therapeuticsSemantic proximity Read ↗

Single-atom inhibition of oncogenic drivers through cysteine coordinationSemantic proximity Read ↗

Reimagining proteome-wide evaluation of residue-specific bioconjugation chemistriesSemantic proximity Read ↗

Engineering human protein switches for functional control of CARs and transcription factors via oral drug administrationSemantic proximity Read ↗

RIPTACs: A groundbreaking approach to drug discoverySemantic proximity Read ↗

Heterobifunctional proteomimetic polymers for targeted protein degradationSemantic proximity Read ↗

Peptide-Drug Conjugates as Next-Generation Therapeutics: Exploring the Potential and Clinical ProgressSemantic proximity Read ↗

Antibody Conjugates with Unnatural Amino AcidsSemantic proximity Read ↗

Rational design of environmentally responsive antibodies with pH-sensing synthetic amino acidsSemantic proximity Read ↗

Chemically Programmable and Switchable CAR‐T TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.