Article
Effects of smoking and shared epitope on the production of anti-citrullinated peptide antibody in a Japanese adult population.
Arthritis care & research - 1 Dec 2014
Terao Chikashi, Ohmura Koichiro, Ikari Katsunori, Kawaguchi Takahisa, Takahashi Meiko, Setoh Kazuya, Nakayama Takeo, Kosugi Shinji, Sekine Akihiro, Tabara Yasuharu, Taniguchi Atsuo, Momohara Shigeki, Yamanaka Hisashi, Yamada Ryo, Matsuda Fumihiko, Mimori Tsuneyo
Abstract excerpt
OBJECTIVE: Anti-citrullinated peptide antibody (ACPA) and rheumatoid factor (RF) are markers to rheumatoid arthritis (RA). Smoking and shared epitope (SE) in HLA-DRB1 are associated with the production of these autoantibodies in RA. Detailed distribution and characterization of ACPA and RF in the general population have remained unclear. We aimed to evaluate positivity of ACPA and RF in a general Japanese...
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