Article
Association of smoking with the constitution of the anti-cyclic citrullinated peptide response in the absence of HLA-DRB1 shared epitope alleles.
Arthritis and rheumatism - 1 Sept 2007
Verpoort K N, Papendrecht-van der Voort E A M, van der Helm-van Mil A H M, Jol-van der Zijde C M, van Tol M J D, Drijfhout J W, Breedveld F C, de Vries R R P, Huizinga T W J, Toes R E M
Abstract excerpt
OBJECTIVE: Smoking is a risk factor for anti-cyclic citrullinated peptide (anti-CCP) antibody-positive rheumatoid arthritis (RA) in patients with HLA-DRB1 shared epitope (SE) alleles. It is unknown whether smoking influences not only the presence of these antibodies, but also other characteristics of the anti-CCP response, such as isotype usage. The aim of this study was to determine the influence of smoking on...
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