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Article

The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide.

Arthritis and rheumatism - 1 Feb 2007

van der Helm-van Mil Annette H M, Verpoort Kirsten N, le Cessie Saskia, Huizinga Tom W J, de Vries René R P, Toes René E M

Abstract excerpt

OBJECTIVE: The HLA shared epitope (SE) alleles are primarily a risk factor for the presence of antibodies to cyclic citrullinated peptide (anti-CCP antibodies) rather than for the development of rheumatoid arthritis (RA). The SE alleles interact with the environmental risk factor tobacco exposure (TE) for predisposition to anti-CCP+ RA. The objectives of this study were to determine 1) whether different SE...

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Share to Antibodies
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

Share to Peptides, Cyclic

Share to Smoking

Share to Tobacco Products

Source

Identifiers

PMID: 17265477
DOI: 10.1002/art.22373

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide.PMID 17265477Read ↗

Smoking increases rheumatoid arthritis susceptibility in individuals carrying the HLA-DRB1 shared epitope, regardless of rheumatoid factor or anti-cyclic citrullinated peptide antibody status.Semantic proximity Read ↗

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The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis.Semantic proximity Read ↗

Interaction of HLA-DRB1*09:01 and *04:05 with smoking suggests distinctive mechanisms of rheumatoid arthritis susceptibility beyond the shared epitope.Semantic proximity Read ↗

Gene-environment interaction between the DRB1 shared epitope and smoking in the risk of anti-citrullinated protein antibody-positive rheumatoid arthritis: all alleles are important.Semantic proximity Read ↗

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Smoking is a risk factor for anti-CCP antibodies only in rheumatoid arthritis patients who carry HLA-DRB1 shared epitope alleles.Semantic proximity Read ↗

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Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins.Semantic proximity Read ↗

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