Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles.

doi:10.1038/tp.2014.37

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Article

Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles.

Translational psychiatry - 17 Jun 2014

Wankerl M, Miller R, Kirschbaum C, Hennig J, Stalder T, Alexander N

Abstract excerpt

The serotonin transporter (SERT) gene-linked polymorphic region (5-HTTLPR) has been implicated in moderating the link between life stress and depression. However, respective molecular pathways of gene-environment (GxE) interaction are largely unknown. Sustained alterations in SERT gene expression profiles, possibly mediated by epigenetic modifications, are a frequent correlate of depression and may thus...

Topics

Adult
Child
Child Abuse
CpG Islands
DNA Methylation
Depression
Female
Gene-Environment Interaction
Genetic Predisposition to Disease
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pregnancy

Pregnancy Complications

Prenatal Exposure Delayed Effects

RNA, Messenger

Risk Factors

Sequence Analysis, DNA

Serotonin Plasma Membrane Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 24937096
DOI: 10.1038/tp.2014.37
PMCID: PMC4080318

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24937096-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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