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Article

Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles.

Translational psychiatry - 17 Jun 2014

Wankerl M, Miller R, Kirschbaum C, Hennig J, Stalder T, Alexander N

Abstract excerpt

The serotonin transporter (SERT) gene-linked polymorphic region (5-HTTLPR) has been implicated in moderating the link between life stress and depression. However, respective molecular pathways of gene-environment (GxE) interaction are largely unknown. Sustained alterations in SERT gene expression profiles, possibly mediated by epigenetic modifications, are a frequent correlate of depression and may thus...

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PMID: 24937096
DOI: 10.1038/tp.2014.37
PMCID: PMC4080318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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