Article
Early life adversity and serotonin transporter gene variation interact to affect DNA methylation of the corticotropin-releasing factor gene promoter region in the adult rat brain.
Development and psychopathology - 1 Feb 2015
van der Doelen Rick H A, Arnoldussen Ilse A, Ghareh Hussein, van Och Liselot, Homberg Judith R, Kozicz Tamás
Abstract excerpt
The interaction between childhood maltreatment and the serotonin transporter (5-HTT) gene linked polymorphic region has been associated with increased risk to develop major depression. This Gene × Environment interaction has furthermore been linked with increased levels of anxiety and glucocortic...
Topics
- Animals
- Anxiety
- Brain
- Corticotropin-Releasing Hormone
- DNA Methylation
- Depressive Disorder, Major
- Epigenesis, Genetic
- Female
- Genetic Variation
- Genotype
- Male
- Maternal Deprivation
- Paraventricular Hypothalamic Nucleus
- Promoter Regions, Genetic