Article
Early life adversity and serotonin transporter gene variation interact to affect DNA methylation of the corticotropin-releasing factor gene promoter region in the adult rat brain.
Development and psychopathology - 1 Feb 2015
van der Doelen Rick H A, Arnoldussen Ilse A, Ghareh Hussein, van Och Liselot, Homberg Judith R, Kozicz Tamás
Abstract excerpt
The interaction between childhood maltreatment and the serotonin transporter (5-HTT) gene linked polymorphic region has been associated with increased risk to develop major depression. This Gene × Environment interaction has furthermore been linked with increased levels of anxiety and glucocorticoid release upon exposure to stress. Both endophenotypes are regulated by the neuropeptide corticotropin-releasing...
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