Article
DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth.
The Journal of investigative dermatology - 1 Nov 2014
Chung Jin-Sung, Tamura Kyoichi, Cruz Ponciano D, Ariizumi Kiyoshi
Abstract excerpt
A major barrier to successful cancer immunotherapy is the tumor's ability to induce T-cell tolerance by exploiting host regulatory mechanisms. Having discovered the DC-HIL receptor, which inhibits T-cell responses by binding to syndecan-4 on effector T cells, we posited the DC-HIL/syndecan-4 path...
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