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Article

IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2009

Sikora Andrew G, Jaffarzad Nina, Hailemichael Yared, Gelbard Alexander, Stonier Spencer W, Schluns Kimberly S, Frasca Loredana, Lou Yanyan, Liu Chengwen, Andersson Helen A, Hwu Patrick, Overwijk Willem W

Abstract excerpt

Type I IFNs, including IFN-alpha, enhance Ag presentation and promote the expansion, survival, and effector function of CD8(+) CTL during viral infection. Because these are ideal characteristics for a vaccine adjuvant, we examined the efficacy and mechanism of exogenous IFN-alpha as an adjuvant for antimelanoma peptide vaccination. We studied the expansion of pmel-1 transgenic CD8(+) T cells specific for the...

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Identifiers

PMID: 19494262
DOI: 10.4049/jimmunol.0802982
PMCID: PMC2774140

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