Article

Metastasis founder cells activate immunosuppression early in human melanoma metastatic colonization

2024-05-11

Abstract excerpt

The earliest steps of lethal metastasis in patients are incompletely understood. To dissect them, we prospectively searched for the earliest detectable disseminated cancer cells (DCC) in sentinel lymph node biopsies of 492 stage I-III patients. By visually-controlled, micromanipulator-assisted isolation and single cell transcriptome analysis of these extremely rare DCC, we identified MCSP + melanoma cells as stro...

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Literature Corpus work: 5bd7ba05-a37a-58b3-8ba7-b151963f7755
DOI: 10.1101/2024.05.08.591627

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