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Article

R270C polymorphism leads to loss of function of the canine P2X7 receptor.

Physiological genomics - 15 Jul 2014

Spildrejorde Mari, Bartlett Rachael, Stokes Leanne, Jalilian Iman, Peranec Michelle, Sluyter Vanessa, Curtis Belinda L, Skarratt Kristen K, Skora Amanda, Bakhsh Tahani, Seavers Aine, McArthur Jason D, Dowton Mark, Sluyter Ronald

Abstract excerpt

The relative function of the P2X7 receptor, an ATP-gated ion channel, varies between humans due to polymorphisms in the P2RX7 gene. This study aimed to assess the functional impact of P2X7 variation in a random sample of the canine population. Blood and genomic DNA were obtained from 69 dogs selected as representatives of a cross section of different breeds. P2X7 function was determined by flow cytometric...

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PMID: 24824213
DOI: 10.1152/physiolgenomics.00195.2013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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