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Article

Genetic variation in P2RX7 and pain tolerance.

Pain - 1 Jun 2018

Kambur Oleg, Kaunisto Mari A, Winsvold Bendik S, Wilsgaard Tom, Stubhaug Audun, Zwart John A, Kalso Eija, Nielsen Christopher S

Abstract excerpt

P2X7 is a nonselective cation channel activated by extracellular ATP. P2X7 activation contributes to the proinflammatory response to injury or bacterial invasion and mediates apoptosis. Recently, P2X7 function has been linked to chronic inflammatory and neuropathic pain. P2X7 may contribute to pain modulation both by effects on peripheral tissue injury underlying clinical pain states, and through alterations in...

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Identifiers

PMID: 29470314
DOI: 10.1097/j.pain.0000000000001188
PMCID: PMC5965926

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