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Article

Critical cysteines in Akt1 regulate its activity and proteasomal degradation: implications for neurodegenerative diseases.

Free radical biology & medicine - 1 Sept 2014

Ahmad Faraz, Nidadavolu Prakash, Durgadoss Lalitha, Ravindranath Vijayalakshmi

Abstract excerpt

Impaired Akt1 signaling is observed in neurodegenerative diseases, including Parkinson׳s disease (PD). In PD models oxidative modification of Akt1 leads to its dephosphorylation and consequent loss of its kinase activity. To explore the underlying mechanism we exposed Neuro2A cells to cadmium, a pan inhibitor of protein thiol disulfide oxidoreductases, including glutaredoxin 1 (Grx1), or downregulated Grx1, which...

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PMID: 24933620
DOI: 10.1016/j.freeradbiomed.2014.06.004

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