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Article

Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival.

Human molecular genetics - 1 Nov 2014

Chuang Chia-Lung, Lu Yu-Ning, Wang Hung-Cheng, Chang Hui-Yun

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2) is a complex kinase and mutations in LRRK2 are perhaps the most common genetic cause of Parkinson's disease (PD). However, the identification of the normal physiological function of LRRK2 remains elusive. Here, we show that LRRK2 protects neurons against apoptosis induced by the Drosophila genes grim, hid and reaper. Genetic dissection reveals that Akt is the critical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Extracellular Signal-Regulated MAP Kinases

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Source

Identifiers

PMID: 24916379
DOI: 10.1093/hmg/ddu281

Genes

FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival.PMID 24916379Read ↗

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