Article
LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations.
FEBS letters - 21 Jul 2011
Ohta Etsuro, Kawakami Fumitaka, Kubo Makoto, Obata Fumiya
Abstract excerpt
LRRK2 is the causal molecule for autosomal-dominant familial Parkinson's disease, although its true function, including its physiological substrates, remains unknown. Here, using in vitro kinase assay with recombinant proteins, we demonstrated for the first time that LRRK2 directly phosphorylates...
Topics
- Animals
- Cell Line
- Gene Knockdown Techniques
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mutation
- Parkinson Disease
- Phosphorylation
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins c-akt
- Recombinant Proteins
- Signal Transduction