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Article

Germline mutations of TP53 gene in breast cancer.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Sept 2014

Damineni Surekha, Rao Vadlamudi Raghavendra, Kumar Satish, Ravuri Rajasekar Reddy, Kagitha Sailaja, Dunna Nageswara Rao, Digumarthi Raghunadharao, Satti Vishnupriya

Abstract excerpt

Germline alterations of the TP53 gene encoding the p53 protein have been observed in the majority of families with the Li-Fraumeni syndrome, a rare dominantly inherited disorder with breast cancer. Genomic DNA samples of 182 breast cancer cases and 186 controls were sequenced for TP53 mutations in the exon 5-9 and intervening introns 5, 7-9. Direct sequencing was done using Applied Biosystem 3730 DNA analyzer. In...

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Identifiers

PMID: 24929325
DOI: 10.1007/s13277-014-2176-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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