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[Germline mutations of TP53 gene among Chinese families with high risk for breast cancer].

Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Dec 2015

Yang Xiaochen, Hu Zhen, Wu Jiong, Liu Guangyu, Di Genhong, Chen Canming, Hou Yifeng, Huang Xiaoyan, Liu Zhebin, Shen Zhenzhou, Shao Zhimin

Abstract excerpt

OBJECTIVE: To evaluate the role of germline mutations of TP53 gene among a Chinese population with high risk for breast cancer. METHODS: A total of 81 BRCA-negative breast cancer probands from cancer families were analyzed using targeted capture and next-generation sequencing. Candidate mutations were verified with Sanger sequencing. Co-segregation analyses were carried out to explore the likely pathogenicity of...

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Identifiers

PMID: 26663043
DOI: 10.3760/cma.j.issn.1003-9406.2015.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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