Clinical and Pathologic Phenotyping of Mesotheliomas Developing in Carriers of Germline BAP1 Mutations.

doi:10.1016/j.jtho.2025.06.020

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Article

Clinical and Pathologic Phenotyping of Mesotheliomas Developing in Carriers of Germline BAP1 Mutations.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2025

Carbone Michele, Minaai Michael, Kittaneh Muaiad, Krausz Thomas, Miettinen Markku M, Pan Hammarström Qiang, Hammarström Lennart, Abolhassani Hassan, Pagano Ian, Xu Ronghui, Novelli Flavia, Gaudino Giovanni, Pastorino Sandra, Sarin Kavita Y, Ripley Robert T, Pass Harvey I, Schrump David S, Yang Haining

Abstract excerpt

INTRODUCTION: Mesothelioma is frequent among carriers of inactivating heterozygous germline BAP1 mutations (BAP1+/-). We studied whether the natural history and the pathology of mesotheliomas in BAP1+/- carriers differed from sporadic, not genetically related, mesotheliomas. METHODS: During 1999 to 2024, we studied 47 families carrying BAP1+/- transmitted in a Mendelian fashion. We characterized these mutations,...

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Identifiers

PMID: 40582407
DOI: 10.1016/j.jtho.2025.06.020
PMCID: PMC12303596

Genes

BAP1

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