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Article

Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations.

Cancer research - 1 May 2016

Kadariya Yuwaraj, Cheung Mitchell, Xu Jinfei, Pei Jianming, Sementino Eleonora, Menges Craig W, Cai Kathy Q, Rauscher Frank J, Klein-Szanto Andres J, Testa Joseph R

Abstract excerpt

Individuals harboring inherited heterozygous germline mutations in BAP1 are predisposed to a range of benign and malignant tumor types, including malignant mesothelioma, melanoma, and kidney carcinoma. However, evidence to support a tumor-suppressive role for BAP1 in cancer remains contradictory. To test experimentally whether BAP1 behaves as a tumor suppressor, we monitored spontaneous tumor development in three...

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Source

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Identifiers

PMID: 26896281
DOI: 10.1158/0008-5472.CAN-15-3371
PMCID: PMC4873414

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations.PMID 26896281Read ↗

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