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The histone methyltransferase KMT2D is essential for embryo implantation via regulating precise differentiation of endometrial cells

8 Aug 2024

Abstract excerpt

Embryo implantation failures are a major challenge in reproductive medicine, but the underlying mechanism remains poorly understood. Successful implantation requires dynamic remodeling of the endometrium through integrated proliferation and differentiation of endometrial cells including luminal epithelial, glandular epithelial, and stromal cells. Conversely, their disruption causes infertility. Spatiotemporal...

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PMID: 39117610
DOI: 10.1038/s41420-024-02134-9

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