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Article

The positive inside rule is stronger when followed by a transmembrane helix.

Journal of molecular biology - 12 Aug 2014

Virkki Minttu T, Peters Christoph, Nilsson Daniel, Sörensen Therese, Cristobal Susana, Wallner Björn, Elofsson Arne

Abstract excerpt

The translocon recognizes transmembrane helices with sufficient level of hydrophobicity and inserts them into the membrane. However, sometimes less hydrophobic helices are also recognized. Positive inside rule, orientational preferences of and specific interactions with neighboring helices have b...

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PMID: 24927974
DOI: 10.1016/j.jmb.2014.06.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24927974-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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