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Article

Initial steps in protein membrane insertion. Bacteriophage M13 procoat protein binds to the membrane surface by electrostatic interaction.

The EMBO journal - 1 Sept 1990

Gallusser A, Kuhn A

Abstract excerpt

Bacteriophage M13 procoat protein is synthesized on free polysomes prior to its assembly into the inner membrane of Escherichia coli. As an initial step of the membrane insertion pathway, the precursor protein interacts with the cytoplasmic face of the inner membrane. We have used oligonucleotide-directed mutagenesis to study the regions of the procoat protein involved in membrane binding. We find that there is...

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Identifiers

PMID: 2202592
DOI: 10.1002/j.1460-2075.1990.tb07459.x
PMCID: PMC551979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Initial steps in protein membrane insertion. Bacteriophage M13 procoat protein binds to the membrane surface by electrostatic interaction.PMID 2202592Read ↗

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Synergistic insertion of two hydrophobic regions drives Sec-independent membrane protein assembly.Semantic proximity Read ↗

Efficient translocation of positively charged residues of M13 procoat protein across the membrane excludes electrophoresis as the primary force for membrane insertion.Semantic proximity Read ↗

The translocation of negatively charged residues across the membrane is driven by the electrochemical potential: evidence for an electrophoresis-like membrane transfer mechanism.Semantic proximity Read ↗

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Sequential model of phage PRD1 DNA delivery: active involvement of the viral membrane.Semantic proximity Read ↗

Functional integration of a polytopic membrane protein of E. coli requires the bacterial signal recognition particle.Semantic proximity Read ↗

Indecisive M13 procoat protein mutants bind to SecA but do not activate the translocation ATPase.Semantic proximity Read ↗

Insertion of bitopic membrane proteins into the inner membrane of mitochondria involves an export step from the matrix.Semantic proximity Read ↗

Expression of membrane proteins at the Escherichia coli membrane for structural studies.Semantic proximity Read ↗

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Structure of membrane-embedded M13 major coat protein is insensitive to hydrophobic stress.Semantic proximity Read ↗

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