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Article

Formation of cytoplasmic turns between two closely spaced transmembrane helices during membrane protein integration into the ER membrane.

Journal of molecular biology - 4 Aug 2000

Sääf A, Hermansson M, von Heijne G

Abstract excerpt

The helical hairpin, two closely spaced transmembrane helices separated by a short turn, is a recurring structural element in integral membrane proteins, and may serve as a compact unit that inserts into the membrane en bloc. Previously, we have determined the propensities of the 20 natural amino acids, when present in the middle of a long hydrophobic stretch, to induce the formation of a helical hairpin with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10926501
DOI: 10.1006/jmbi.2000.3933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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