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Article

Filaggrin gene mutations in African Americans with both ichthyosis vulgaris and atopic dermatitis.

Pediatric dermatology - 1 Jan 2000

Polcari Ingrid, Becker Lauren, Stein Sarah L, Smith Marilyn S, Paller Amy S

Abstract excerpt

Atopic dermatitis (AD) and ichthyosis vulgaris (IV) are two common disorders of epidermal homeostasis resulting in dry skin. The profilaggrin gene, located on chromosome 1q22, encodes a keratin filament aggregating protein (filaggrin) that is essential to forming the epidermal barrier and maintaining hydration. Null mutations in filaggrin have been found to underlie IV and are common in patients with AD, but the...

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Source

Identifiers

PMID: 24920311
DOI: 10.1111/pde.12355

Genes

FLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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