Article
Analyses of FLG mutation frequency and filaggrin expression in isolated ichthyosis vulgaris (IV) and atopic dermatitis-associated IV.
The British journal of dermatology - 1 Jun 2013
Li M, Cheng R, Shi M, Liu J, Zhang G, Liu Q, Yu H, Yao Z
Abstract excerpt
BACKGROUND: Ichthyosis vulgaris (IV; OMIM 146700) is a very common inherited skin disorder. Loss-of-function mutations in the filaggrin gene (FLG) have been identified as the cause of IV. In a previous study, we found that the percentage of FLG null mutations was lower in IV associated with atopic dermatitis (AD) than in IV not associated with AD (isolated IV). We speculated that some clinical manifestations of...
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