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Article

Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case-control study.

Journal of human genetics - 1 Jan 2008

Enomoto Hisako, Hirata Kenji, Otsuka Kenta, Kawai Toshiharu, Takahashi Takenori, Hirota Tomomitsu, Suzuki Yoichi, Tamari Mayumi, Otsuka Fujio, Fujieda Shigeharu, Arinami Tadao, Noguchi Emiko

Abstract excerpt

Filaggrin (FLG) plays an important role in the barrier function of the skin. Several loss-of-function mutations in the FLG gene have been identified in patients with ichthyosis vulgaris, and these null mutations are associated with atopic dermatitis (AD) development. In this study, we examined tag single nucleotide polymorphisms (tSNPs) and null mutations in FLG for possible associations with AD and atopic...

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Identifiers

PMID: 18521703
DOI: 10.1007/s10038-008-0293-z

Genes

FLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Filaggrin null mutations are associated with atopic dermatitis and elevated levels of IgE in the Japanese population: a family and case-control study.PMID 18521703Read ↗

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