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Article

Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis.

The Journal of allergy and clinical immunology - 1 Feb 2007

Nomura Toshifumi, Sandilands Aileen, Akiyama Masashi, Liao Haihui, Evans Alan T, Sakai Kaori, Ota Mitsuhito, Sugiura Hisashi, Yamamoto Kazuo, Sato Hiroshi, Palmer Colin N A, Smith Frances J D, McLean W H Irwin, Shimizu Hiroshi

Abstract excerpt

BACKGROUND: Filaggrin is a key protein involved in skin barrier function. Recently, mutations in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV) and shown to be an important predisposing factor for atopic dermatitis (AD). OBJECTIVE: To study the role of FLG mutations in IV/AD in Japan. METHODS: The known filaggrin mutations were studied by genotyping and new mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17291859
DOI: 10.1016/j.jaci.2006.12.646

Genes

FLG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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