Article
Wide spectrum of filaggrin-null mutations in atopic dermatitis highlights differences between Singaporean Chinese and European populations.
The British journal of dermatology - 1 Jul 2011
Chen H, Common J E A, Haines R L, Balakrishnan A, Brown S J, Goh C S M, Cordell H J, Sandilands A, Campbell L E, Kroboth K, Irvine A D, Goh D L M, Tang M B Y, van Bever H P, Giam Y C, McLean W H I, Lane E B
Abstract excerpt
BACKGROUND: Null mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris (IV) and predispose to atopic dermatitis (AD). Cohort studies in Europe and Japan have reported an FLG mutation carrier frequency of between 14% and 56%, but the prevalent European FLG mutations are rare or absent in Chinese patients with IV and AD. OBJECTIVES: To investigate further the spectrum of FLG-null mutations in Chinese...
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