Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oxidative stress promotes myofibroblast differentiation and tumour spreading

1 Jun 2010

Abstract excerpt

JunD regulates genes involved in antioxidant defence. We took advantage of the chronic oxidative stress resulting from junD deletion to examine the role of reactive oxygen species (ROS) in tumour development. In a model of mammary carcinogenesis, junD inactivation increased tumour incidence and revealed an associated reactive stroma. junD-inactivation in the stroma was sufficient to shorten tumour-free survival...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Cancer-related Molecular Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20535745
DOI: 10.1002/emmm.201000073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oxidative stress promotes myofibroblast differentiation and tumour spreadingPMID 20535745Read ↗

The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases.Semantic proximity Read ↗

The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and ProgressionSemantic proximity Read ↗

Role of oxidative stress and the microenvironment in breast cancer development and progression.Semantic proximity Read ↗

JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer preventionSemantic proximity Read ↗

ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasionSemantic proximity Read ↗

c-Jun induces mammary epithelial cellular invasion and breast cancer stem cell expansion.Semantic proximity Read ↗

Peroxiredoxin-2 represses NRAS-mutated melanoma cells invasion by modulating EMT markers.Semantic proximity Read ↗

Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasisSemantic proximity Read ↗

Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.Semantic proximity Read ↗

A novel crosstalk between Nrf2 and Smad2/3 bridged by two nuanced Keap1 isoformsSemantic proximity Read ↗

IKKα regulates human keratinocyte migration through surveillance of the redox environmentSemantic proximity Read ↗

S-Nitrosylated COX-2 is a TME-regulated breast cancer biomarker of mesenchymal phenotypesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.