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Article

Neuronal production of lipocalin-2 as a help-me signal for glial activation.

Stroke - 1 Jul 2014

Xing Changhong, Wang Xiaoshu, Cheng Chongjie, Montaner Joan, Mandeville Emiri, Leung Wendy, van Leyen Klaus, Lok Josephine, Wang Xiaoying, Lo Eng H

Abstract excerpt

BACKGROUND AND PURPOSE: We explored the hypothesis that injured neurons release lipocalin-2 as a help me signal. METHODS: In vivo lipocalin-2 responses were assessed in rat focal cerebral ischemia and human stroke brain samples using a combination of ELISA and immunostaining. In vitro, microglia and astrocytes were exposed to lipocalin-2, and various markers and assays of glial activation were quantified....

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Identifiers

PMID: 24916903
DOI: 10.1161/STROKEAHA.114.005733
PMCID: PMC4122238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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