Article
Toll-Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) Activation Balance Astrocyte Polarization into a Proinflammatory Phenotype.
Molecular neurobiology - 1 May 2018
Rosciszewski Gerardo, Cadena Vanesa, Murta Veronica, Lukin Jeronimo, Villarreal Alejandro, Roger Thierry, Ramos Alberto Javier
Abstract excerpt
Astrocytes react to brain injury with a generic response known as reactive gliosis, which involves activation of multiple intracellular pathways including several that may be beneficial for neuronal survival. However, by unknown mechanisms, reactive astrocytes can polarize into a proinflammatory phenotype that induces neurodegeneration. In order to study reactive gliosis and astroglial polarization into a...
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