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Article

The Fc gamma receptor IIa R131H polymorphism is associated with inhibitor development in severe hemophilia A.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2014

Eckhardt C L, Astermark J, Nagelkerke S Q, Geissler J, Tanck M W T, Peters M, Fijnvandraat K, Kuijpers T W

Abstract excerpt

BACKGROUND: The development of factor (F) VIII neutralizing alloantibodies (inhibitors) is a major complication of treatment with FVIII concentrates in hemophilia A and the etiology is still poorly understood. The low-affinity Fc gamma receptors (FcγR), which are expressed on immune cells, provide an important link between cellular and humoral immunity by interacting with IgG subtypes. Genetic variations of the...

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Source

Identifiers

PMID: 24916518
DOI: 10.1111/jth.12631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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