Article
[Study of polymorphism of Fc gamma IIa receptors in Chilean patients with systemic lupus erythematosus].
Revista medica de Chile - 1 Jan 2003
Carrión Flavio, Figueroa Fernando, Martínez M Eugenia, Massardo Loreto, Pérez Tamara, Foster Carolina, Mancilla Cecilia, Neira Oscar, Guzmán Leonardo, Valenzuela Viviana, Urrutia Ramón, Carmona Sergio, Figueroa Maximiliano, Lubiano Alessandra, Wainstein Eduardo
Abstract excerpt
BACKGROUND: Polymorphisms of Fc receptors for IgG (Fc gamma R) have been proposed as a genetic factor that influences susceptibility for systemic lupus erythematosus (SLE). Human Fc gamma RIIa has 2 codominantly expressed alleles, H131 and R131, which differ at amino acid position 131 in the second extracellular domain (histidine or arginine respectively) and differ substantially in their ability to bind human...
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