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Article

Rapid detection of DNMT3A R882 mutations in hematologic malignancies using a novel bead-based suspension assay with BNA(NC) probes.

PloS one - 1 Jan 2014

Shivarov Velizar, Ivanova Milena, Naumova Elissaveta

Abstract excerpt

Mutations in the human DNA methyl transferase 3A (DNMT3A) gene are recurrently identified in several hematologic malignancies such as Philadelphia chromosome-negative myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), MPN/MDS overlap syndromes and acute myeloid leukemia (AML). They have been shown to confer worse prognosis in some of these entities. Notably, about 2/3 of these mutations are...

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Identifiers

PMID: 24914952
DOI: 10.1371/journal.pone.0099769
PMCID: PMC4051762

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