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Article

Detection of high-frequency and novel DNMT3A mutations in acute myeloid leukemia by high-resolution melting curve analysis.

The Journal of molecular diagnostics : JMD - 1 Jul 2012

Singh Rajesh R, Bains Ashish, Patel Keyur P, Rahimi Hamed, Barkoh Bedia A, Paladugu Abhaya, Bisrat Tigist, Ravandi-Kashani Farhad, Cortes Jorge E, Kantarjian Hagop M, Medeiros L Jeffrey, Luthra Rajyalakshmi

Abstract excerpt

DNA methyltransferase 3A (DNMT3A) is mutated in a subset of de novo acute myeloid leukemia patients and is associated with poor overall and event-free survival. Because routine Sanger sequencing of the 23 DNMT3A exons is impractical in clinical laboratories, we developed a high-throughput method using high-resolution melting (HRM) analysis, which identifies sequence variants by detecting subtle changes in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22642896
DOI: 10.1016/j.jmoldx.2012.02.009
PMCID: PMC5707199

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