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[Evaluation of the correlation between JAK2V617F allele burden by Quenching Probe-Tm method and allele-specific quantitative PCR method].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Jan 2022

Yamada Seiko, Kondo Toshinori, Uchida Keiichi, Hirose Tadashi, Takeuchi Asako, Shimizu-Koresawa Risa, Matsuhashi Yoshiko, Kondo Eisei, Tohyama Kaoru, Wada Hideho

Abstract excerpt

The JAK2V617F mutation is a driver mutation of myeloproliferative neoplasms (MPNs). V617F allele burden is considered a risk factor for complications associated with MPNs and is a predictor of prognosis. In Japan, V617F allele burden has been measured in laboratory settings using the i-densyTM IS-5320 genetic analyzer with the quenching probe-Tm (QP-Tm) method. However, since 2020, allele-specific quantitative...

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PMID: 35135945
DOI: 10.11406/rinketsu.63.1

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