Article
Two novel methods for rapid detection and quantification of DNMT3A R882 mutations in acute myeloid leukemia.
The Journal of molecular diagnostics : JMD - 1 Mar 2015
Mancini Melissa, Hasan Syed Khizer, Ottone Tiziana, Lavorgna Serena, Ciardi Claudia, Angelini Daniela F, Agostini Francesca, Venditti Adriano, Lo-Coco Francesco
Abstract excerpt
DNMT3A mutations represent one of the most frequent gene alterations detectable in acute myeloid leukemia with normal karyotype. Although various recurrent somatic mutations of DNMT3A have been described, the most common mutation is located at amino acid R882 in the methyltransferase domain of the gene. DNMT3A mutations have been reported to be stable during disease progression and are associated with unfavorable...
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