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DISCERN: Dual-Aptamer-Initiated Sensing Circuit via Engineered Nanozyme for Leukemia Stem Cells Phenotyping.

ACS sensors - 27 Feb 2026

Shi Hai, Liu Lu, Shen Ying, Xiao Yunlong, Mu Renwu, Zhai Suzhen, Zhang Bin, Yang Xiaoyan, Zhang Chunlin

Abstract excerpt

Leukemia stem cell (LSC) phenotyping offers significant potential to enhance minimal residual disease (MRD) monitoring in acute myeloid leukemia (AML), improving therapeutic evaluation and relapse prediction. However, current approaches lack the sufficient sensitivity and specificity to reliably detect rare chemotherapy-resistant LSCs (crLSCs) or identify stem-like phenotypic states, limiting clinical...

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Identifiers

PMID: 41643149
DOI: 10.1021/acssensors.5c03906

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CD33

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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