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Article

Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia.

Journal of experimental & clinical cancer research : CR - 22 May 2015

Berenstein Rimma, Blau Igor Wolfgang, Suckert Nikola, Baldus Claudia, Pezzutto Antonio, Dörken Bernd, Blau Olga

Abstract excerpt

BACKGROUND: DNMT3A mutations represent one of the most frequent gene alterations detectable in acute myeloid leukemia (AML) with normal karyotype. Although various recurrent somatic mutations of DNMT3A have been described, the most common mutation is located at R882 in the methyltransferase domain of the gene. Because of their prognostic significance and high stability during disease evolution, DNMT3A mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 25994761
DOI: 10.1186/s13046-015-0173-2
PMCID: PMC4443651

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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