Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner.

Journal of bacteriology - 15 Aug 2014

Bao Xiaofeng, Gylfe Asa, Sturdevant Gail L, Gong Zheng, Xu Shuang, Caldwell Harlan D, Elofsson Mikael, Fan Huizhou

Abstract excerpt

Chlamydiae are widespread Gram-negative pathogens of humans and animals. Salicylidene acylhydrazides, developed as inhibitors of type III secretion system (T3SS) in Yersinia spp., have an inhibitory effect on chlamydial infection. However, these inhibitors also have the capacity to chelate iron, and it is possible that their antichlamydial effects are caused by iron starvation. Therefore, we have explored the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Molecular Sequence Data

Share to Polymorphism, Single Nucleotide

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 24914180
DOI: 10.1128/JB.01677-14
PMCID: PMC4135636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner.PMID 24914180Read ↗

Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity.Semantic proximity Read ↗

The Bacterial Type <scp>III</scp> Secretion System as a Target for Developing New AntibioticsSemantic proximity Read ↗

Isolation of Salmonella mutants resistant to the inhibitory effect of Salicylidene acylhydrazides on flagella-mediated motility.Semantic proximity Read ↗

GrgA as a potential target of selective antichlamydialsSemantic proximity Read ↗

Structural characterisation of spirosomes and its link to Escherichia coli O157:H7 virulenceSemantic proximity Read ↗

Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.Semantic proximity Read ↗

The salicylidene acylhydrazide INP0341 attenuates Pseudomonas aeruginosa virulence in vitro and in vivo.Semantic proximity Read ↗

AdhE spirosome length in enterohaemorrhagic <i>Escherichia coli</i> is correlated with enzymatic directionality and is perturbed by salicylidene acylhydrazide bindingSemantic proximity Read ↗

Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds.Semantic proximity Read ↗

Azurin of pathogenic Neisseria spp. is involved in defense against hydrogen peroxide and survival within cervical epithelial cells.Semantic proximity Read ↗

Structure-based mutational studies of O-acetylserine sulfhydrylase reveal the reason for the loss of cysteine synthase complex formation in Brucella abortus.Semantic proximity Read ↗

Chloramphenicol acetyltransferase as a selection marker for chlamydial transformationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.