Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.

Antimicrobial agents and chemotherapy - 1 Aug 2012

Sandoz Kelsi M, Eriksen Steven G, Jeffrey Brendan M, Suchland Robert J, Putman Timothy E, Hruby Dennis E, Jordan Robert, Rockey Daniel D

Abstract excerpt

A novel and quantitative high-throughput screening approach was explored as a tool for the identification of novel compounds that inhibit chlamydial growth in mammalian cells. The assay is based on accumulation of a fluorescent marker by intracellular chlamydiae. Its utility was demonstrated by screening 42,000 chemically defined compounds against Chlamydia caviae GPIC. This analysis led to the identification of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line

Share to Ceramides

Share to Chlamydia trachomatis

Share to Drug Resistance, Bacterial

Share to Microbial Sensitivity Tests

Share to Quinolines

Source

Open in PubMed Open full text

Identifiers

PMID: 22644029
DOI: 10.1128/AAC.00356-12
PMCID: PMC3421553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Resistance to a novel antichlamydial compound is mediated through mutations in Chlamydia trachomatis secY.PMID 22644029Read ↗

Developing Cyclic Peptomers as Broad-Spectrum Gram negative Bacterial Type III Secretion System InhibitorsSemantic proximity Read ↗

Benzylidene acylhydrazides inhibit chlamydial growth in a type III secretion- and iron chelation-independent manner.Semantic proximity Read ↗

A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis.Semantic proximity Read ↗

Chlamydia trachomatis clinical isolates identified as tetracycline resistant do not exhibit resistance in vitro: whole-genome sequencing reveals a mutation in porB but no evidence for tetracycline resistance genes.Semantic proximity Read ↗

Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity.Semantic proximity Read ↗

Development of an sRNA-mediated conditional knockdown system for Chlamydia trachomatisSemantic proximity Read ↗

Characterization of trimethoprim- and sulphisoxazole-resistant Chlamydia trachomatis.Semantic proximity Read ↗

Chloramphenicol acetyltransferase as a selection marker for chlamydial transformationSemantic proximity Read ↗

Selection of mutant cell lines resistant to infection by Chlamydia spp [corrected].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.