Article
Mutations in hemG mediate resistance to salicylidene acylhydrazides, demonstrating a novel link between protoporphyrinogen oxidase (HemG) and Chlamydia trachomatis infectivity.
Journal of bacteriology - 1 Sept 2013
Engström Patrik, Nguyen Bidong D, Normark Johan, Nilsson Ingela, Bastidas Robert J, Gylfe Asa, Elofsson Mikael, Fields Kenneth A, Valdivia Raphael H, Wolf-Watz Hans, Bergström Sven
Abstract excerpt
Salicylidene acylhydrazides (SAHs) inhibit the type III secretion system (T3S) of Yersinia and other Gram-negative bacteria. In addition, SAHs restrict the growth and development of Chlamydia species. However, since the inhibition of Chlamydia growth by SAH is suppressed by the addition of excess...
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