Article
Structural characterisation of Tpx from Yersinia pseudotuberculosis reveals insights into the binding of salicylidene acylhydrazide compounds.
PloS one - 1 Jan 2012
Gabrielsen Mads, Beckham Katherine S H, Feher Victoria A, Zetterström Caroline E, Wang Dai, Müller Sylke, Elofsson Mikael, Amaro Rommie E, Byron Olwyn, Roe Andrew J
Abstract excerpt
Thiol peroxidase, Tpx, has been shown to be a target protein of the salicylidene acylhydrazide class of antivirulence compounds. In this study we present the crystal structures of Tpx from Y. pseudotuberculosis (ypTpx) in the oxidised and reduced states, together with the structure of the C61S mu...
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