Article
The ARL2 GTPase is required for mitochondrial morphology, motility, and maintenance of ATP levels.
PloS one - 1 Jan 2014
Newman Laura E, Zhou Cheng-jing, Mudigonda Samatha, Mattheyses Alexa L, Paradies Eleonora, Marobbio Carlo Marya Thomas, Kahn Richard A
Abstract excerpt
ARF-like 2 (ARL2) is a member of the ARF family and RAS superfamily of regulatory GTPases, predicted to be present in the last eukaryotic common ancestor, and essential in a number of model genetic systems. Though best studied as a regulator of tubulin folding, we previously demonstrated that ARL2 partially localizes to mitochondria. Here, we show that ARL2 is essential to a number of mitochondrial functions,...
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