A single nucleotide polymorphism in PIK3CA gene is inversely associated with P53 protein expression in breast cancer.

doi:10.1007/s12032-014-0030-8

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Article

A single nucleotide polymorphism in PIK3CA gene is inversely associated with P53 protein expression in breast cancer.

Medical oncology (Northwood, London, England) - 1 Jul 2014

Pang Bo, Sun Shi-Peng, Gao Lei, Zhu Rui-Li, Zhang Li-xin, An Cheng, Liu Zhi-Yuan, Liu Gui-Jian

Abstract excerpt

Single nucleotide polymorphism (SNP) rs17849071 was recently reported to be inversely associated with PIK3CA amplification in follicular thyroid cancer, but the main function of this SNP remains unclear. In this study, by using PCR and sequencing method, we explored whether this SNP was associated with P53 expression status and other clinicopathological characteristics in 62 Chinese breast cancer (BCa) patients....

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PMID: 24908061
DOI: 10.1007/s12032-014-0030-8

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