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Article

Influence of TCF7L2 gene variants on the therapeutic response to the dipeptidylpeptidase-4 inhibitor linagliptin.

Diabetologia - 1 Sept 2014

Zimdahl Heike, Ittrich Carina, Graefe-Mody Ulrike, Boehm Bernhard O, Mark Michael, Woerle Hans-Juergen, Dugi Klaus A

Abstract excerpt

AIMS/HYPOTHESIS: Individuals carrying variants of the transcription factor 7-like 2 gene (TCF7L2) are at increased risk for type 2 diabetes. These metabolic genetic risk factors have been linked to diminished pancreatic islet-cell responsiveness to incretins, thus pharmacological interventions aimed at amplifying endogenous incretin biology may be affected. However, clinical evidence from randomised controlled...

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Identifiers

PMID: 24906949
DOI: 10.1007/s00125-014-3276-y
PMCID: PMC4119242

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