Article
The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies.
Diabetic medicine : a journal of the British Diabetic Association - 1 Oct 2007
De Silva N M G, Steele A, Shields B, Knight B, Parnell K, Weedon M N, Hattersley A T, Frayling T M
Abstract excerpt
AIMS: Common polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are strongly associated with Type 2 diabetes. Many studies include a large proportion of cases enriched for family history or young age of diagnosis and may therefore provide an overestimation of the general population risk. We aimed to compare the impact of TCF7L2 in UK community-based Type 2 diabetic subjects with that in subjects...
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