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Metformin Alters Human Host Responses to Mycobacterium tuberculosis in Healthy Subjects

8 Feb 2019

Abstract excerpt

BACKGROUND: Metformin, the most widely administered diabetes drug, has been proposed as a candidate adjunctive host-directed therapy for tuberculosis, but little is known about its effects on human host responses to Mycobacterium tuberculosis. METHODS: We investigated in vitro and in vivo effects of metformin in humans. RESULTS: Metformin added to peripheral blood mononuclear cells from healthy volunteers...

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PMID: 30753544
DOI: 10.1093/infdis/jiz064

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