Genetic predictors of long-term response to growth hormone (GH) therapy in children with GH deficiency and Turner syndrome: the influence of a SOCS2 polymorphism.

doi:10.1210/jc.2014-1744

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genetic predictors of long-term response to growth hormone (GH) therapy in children with GH deficiency and Turner syndrome: the influence of a SOCS2 polymorphism.

The Journal of clinical endocrinology and metabolism - 1 Sept 2014

Braz Adriana F, Costalonga Everlayny F, Trarbach Ericka B, Scalco Renata C, Malaquias Alexsandra C, Guerra-Junior Gil, Antonini Sonir R R, Mendonca Berenice B, Arnhold Ivo J P, Jorge Alexander A L

Abstract excerpt

BACKGROUND: There is great interindividual variability in the response to GH therapy. Ascertaining genetic factors can improve the accuracy of growth response predictions. Suppressor of cytokine signaling (SOCS)-2 is an intracellular negative regulator of GH receptor (GHR) signaling. OBJECTIVE: The objective of the study was to assess the influence of a SOCS2 polymorphism (rs3782415) and its interactive effect...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Growth Disorders

Share to Growth Hormone

Share to Human Growth Hormone

Share to Suppressor of Cytokine Signaling Proteins

Share to Treatment Outcome

Share to Turner Syndrome

Source

Open in PubMed

Identifiers

PMID: 24905066
DOI: 10.1210/jc.2014-1744

Genes

SOCS2
GHR
IGFBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic predictors of long-term response to growth hormone (GH) therapy in children with GH deficiency and Turner syndrome: the influence of a SOCS2 polymorphism.PMID 24905066Read ↗

The interactive effect of GHR-exon 3 and -202 A/C IGFBP3 polymorphisms on rhGH responsiveness and treatment outcomes in patients with Turner syndrome.Semantic proximity Read ↗

A pharmacogenomic approach to the treatment of children with GH deficiency or Turner syndrome.Semantic proximity Read ↗

Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study.Semantic proximity Read ↗

A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness.Semantic proximity Read ↗

SNPs within the GH-signaling pathway are associated with the early IGF1 response to GH replacement therapy in GHD adults.Semantic proximity Read ↗

DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhoodSemantic proximity Read ↗

Gene expression signatures predict response to therapy with growth hormoneSemantic proximity Read ↗

DNA methylation at the suppressor of cytokine signaling 3 ( <i>SOCS3</i> ) gene influences height in childhoodSemantic proximity Read ↗

SOCS2 polymorphisms are not associated with clinical and biochemical phenotypes in acromegalic patients.Semantic proximity Read ↗

Lack of Socs2 expression causes the high-growth phenotype in mice.Semantic proximity Read ↗

Association of the (CA)n repeat polymorphism of insulin-like growth factor-I and -202 A/C IGF-binding protein-3 promoter polymorphism with adult height in patients with severe growth hormone deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.